Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Occurrence of low frequency PIK3CA and AKT2 mutations in gastric cancer.

Mutation research - 1 Nov 2014

Zhang Qing-Ying, Cheng Wen-Xiang, Li Wen-Mei, Au William, Lu You-Yong

Abstract excerpt

The PI3K/AKT signal transduction pathway has distinct functional roles in tumor progression. PIK3CA was reported to harbor the hot-spot in many types of tumor. Akt, the downstream of PI3K, its family members especially AKT2 activation in human cancer has been extensively studied, but its activation by mutation was less reported. The occurrence of PIK3CA and AKT2 mutations in a variety of cancers indicates their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Case-Control Studies
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Gene Frequency

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Stomach Neoplasms

Source

Identifiers

PMID: 25771729
DOI: 10.1016/j.mrfmmm.2014.07.007

Genes

AKT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Occurrence of low frequency PIK3CA and AKT2 mutations in gastric cancer.PMID 25771729Read ↗

Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer.Semantic proximity Read ↗

A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.Semantic proximity Read ↗

PIK3CA Mutation Analysis in Iranian Patients with Gastric CancerSemantic proximity Read ↗

Genetic variants of autophagy-related genes in the PI3K/Akt/mTOR pathway and risk of gastric cancer in the Chinese population.Semantic proximity Read ↗

Mutations in PI3K/AKT pathway genes and amplifications of PIK3CA are associated with patterns of recurrence in gastric cancers.Semantic proximity Read ↗

Genetic variants in PI3K/Akt/mTOR pathway genes contribute to gastric cancer risk.Semantic proximity Read ↗

PIK3CA mutations are associated with increased tumor aggressiveness and Akt activation in gastric cancerSemantic proximity Read ↗

Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer.Semantic proximity Read ↗

Study on the association between PI3K/AKT/mTOR signaling pathway gene polymorphism and susceptibility to gastric cancer.Semantic proximity Read ↗

Phosphatidylinositol-3-kinase pathway aberrations in gastric and colorectal cancer: meta-analysis, co-occurrence and ethnic variation.Semantic proximity Read ↗

A GG allele of 3'-side AKT1 SNP is associated with decreased AKT1 activation and better prognosis of gastric cancer.Semantic proximity Read ↗

Mutational Analysis of <i>AKT1, AKT2</i> and <i>AKT3</i> Genes in Common Human CarcinomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.