Article
Genetic variants in PI3K/Akt/mTOR pathway genes contribute to gastric cancer risk.
Gene - 5 Sept 2018
Ge Yuqiu, Liu Hanting, Qiu Xiaonan, Ma Gaoxiang, Wang Haixiao, Du Mulong, Wang Meilin, Zhao Qinghong, Tao Guoquan, Chu Haiyan, Zhang Zhengdong
Abstract excerpt
PI3K/Akt/mTOR pathway is involved in tumor initiation and progression, including gastric cancer (GC). However, the single nucleotide polymorphisms (SNPs) in this pathway and underlying molecular mechanism remain largely unexplored. A case-control study of 1275 GC patients and 1436 controls was performed to explore the associations of potentially functional SNPs in PI3K/Akt/mTOR pathway genes with the risk of GC....
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