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Article

Mutations in PI3K/AKT pathway genes and amplifications of PIK3CA are associated with patterns of recurrence in gastric cancers.

Oncotarget - 2 Feb 2016

Fang Wen-Liang, Huang Kuo-Hung, Lan Yuan-Tzu, Lin Chien-Hsing, Chang Shih-Ching, Chen Ming-Huang, Chao Yee, Lin Wen-Chang, Lo Su-Shun, Li Anna Fen-Yau, Wu Chew-Wun, Chiou Shih-Hwa, Shyr Yi-Ming

Abstract excerpt

Mutations in genes involved in the PI3K/AKT pathway and amplifications of the PIK3CA gene in gastric cancer and their associations with clinicopathological characteristics and EBV infection were analyzed in this study. A total of 431 patients with gastric adenocarcinomas were enrolled, and 39 mutation hotspots were evaluated in these patients using MALDI-TOF mass spectrometry were analyzed. PIK3CA amplifications...

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Identifiers

PMID: 26701847
DOI: 10.18632/oncotarget.6641
PMCID: PMC4868750

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