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Article

Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer.

BMC cancer - 1 Feb 2012

Shi Jing, Yao Demao, Liu Wei, Wang Na, Lv Hongjun, Zhang Guanjun, Ji Meiju, Xu Li, He Nongyue, Shi Bingyin, Hou Peng

Abstract excerpt

BACKGROUND: The phosphoinositide 3-kinase (PI3K)/Akt pathway plays a fundamental role in cell proliferation and survival in human tumorigenesis, including gastric cancer. PIK3CA mutations and amplification are two major causes of overactivation of this pathway in human cancers. However, until thi...

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Identifiers

PMID: 22292935
DOI: 10.1186/1471-2407-12-50
PMCID: PMC3299648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22292935-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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