Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PIK3CA Mutation Analysis in Iranian Patients with Gastric Cancer

Iranian biomedical journal - 1 Jan 2019

Iranpour Mostafa, Nourian Mahyar, Saffari Sana, Samizadeh Esmaeil, Mirghafori Mahdieh, Iravani Shahrokh, Ghafouri-Fard Soudeh

Abstract excerpt

Backgrounda: Aberrant activation of phosphatidylinositol-3 kinases (PI3K)/AKT/mTOR (mammalian target of rapamycin) pathway is a critical event during gastric cancer progression. Selective function of AKT inhibitor AZD5363 in PI3KCA mutant gastric cancer necessitates the assessment of PI3KCA mutations in these patients. Methods: The study included 100 patients with gastric cancer who underwent surgical resection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Kaplan-Meier Estimate

Share to Mutation

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 29704890
PMCID: PMC6305827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PIK3CA Mutation Analysis in Iranian Patients with Gastric CancerPMID 29704890Read ↗

PIK3CA mutations are associated with increased tumor aggressiveness and Akt activation in gastric cancerSemantic proximity Read ↗

Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer.Semantic proximity Read ↗

Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer.Semantic proximity Read ↗

Mutations of PIK3CA in gastric adenocarcinoma.Semantic proximity Read ↗

Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review.Semantic proximity Read ↗

Occurrence of low frequency PIK3CA and AKT2 mutations in gastric cancer.Semantic proximity Read ↗

Mutations in PI3K/AKT pathway genes and amplifications of PIK3CA are associated with patterns of recurrence in gastric cancers.Semantic proximity Read ↗

The role of PIK3CA gene mutations in colorectal cancer and the selection of treatment strategiesSemantic proximity Read ↗

The analysis of PIK3CA mutations in gastric carcinoma and metanalysis of literature suggest that exon-selectivity is a signature of cancer type.Semantic proximity Read ↗

Investigation of somatic PIK3CA gene mutations in breast cancer patients.Semantic proximity Read ↗

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches.Semantic proximity Read ↗

Phosphatidylinositol-3-kinase pathway aberrations in gastric and colorectal cancer: meta-analysis, co-occurrence and ethnic variation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.