Article
Chromatin fibers are formed by heterogeneous groups of nucleosomes in vivo.
Cell - 12 Mar 2015
Ricci Maria Aurelia, Manzo Carlo, García-Parajo María Filomena, Lakadamyali Melike, Cosma Maria Pia
Abstract excerpt
Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight into how nucleosomes are arranged in vivo, we combined quantitative super-resolution nanoscopy with computer simulations to visualize and count nucleosomes along the chromatin fiber in single nuclei. Nucleosomes assembled in heterogeneous groups of varying sizes, here termed "clutches," and these were interspersed with...
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