Article

Offspring production of ovarian organoids derived from spermatogonial stem cells by chromatin reorganization

2019-09-10

Abstract excerpt

Fate determination of germline stem cells remains poorly understood at the chromatin structure level 1,2 . Here, we demonstrate successful production of offspring from oocytes transdifferentiated from mouse spermatogonial stem cells (SSCs) with tracking of transplanted SSCs in vivo, single cell whole exome sequencing, and in 3D cell culture reconstitution of the process of oogenesis derived from SSCs. Furthermore...

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Literature Corpus work: aaebd0be-fc98-5504-87c5-110f53749cdb
DOI: 10.1101/764472

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