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Article

Identification and cloning of two putative subunits of DNA polymerase epsilon in fission yeast.

Nucleic acids research - 1 Jan 2004

Spiga Maria-Grazia, D'Urso Gennaro

Abstract excerpt

DNA polymerase epsilon (Pol epsilon) is a multi-subunit enzyme required for the initiation of chromosomal DNA replication. Here, we report the cloning of two fission yeast genes, called dpb3+ and dpb4+ that encode proteins homologous to the two smallest subunits of Pol epsilon. Although Dpb4 is not required for cell viability, Deltadpb4 mutants are synthetically lethal with mutations in four genes required for...

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Identifiers

PMID: 15388803
DOI: 10.1093/nar/gkh811
PMCID: PMC519108

Genes

CDC45

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and cloning of two putative subunits of DNA polymerase epsilon in fission yeast.PMID 15388803Read ↗

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