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Article

Dpb2p, a noncatalytic subunit of DNA polymerase epsilon, contributes to the fidelity of DNA replication in Saccharomyces cerevisiae.

Genetics - 1 Feb 2008

Jaszczur Malgorzata, Flis Krzysztof, Rudzka Justyna, Kraszewska Joanna, Budd Martin E, Polaczek Piotr, Campbell Judith L, Jonczyk Piotr, Fijalkowska Iwona J

Abstract excerpt

Most replicases are multi-subunit complexes. DNA polymerase epsilon from Saccharomyces cerevisiae is composed of four subunits: Pol2p, Dpb2p, Dpb3p, and Dpb4p. Pol2p and Dpb2p are essential. To investigate a possible role for the Dpb2p subunit in maintaining the fidelity of DNA replication, we isolated temperature-sensitive mutants in the DPB2 gene. Several of the newly isolated dpb2 alleles are strong mutators,...

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Identifiers

PMID: 18245343
DOI: 10.1534/genetics.107.082818
PMCID: PMC2248333

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Source receipt: pubmed, retrieved 7 Sept 2026.

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