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Article

Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint.

PLoS genetics - 1 Jan 2017

Dmowski Michał, Rudzka Justyna, Campbell Judith L, Jonczyk Piotr, Fijałkowska Iwona J

Abstract excerpt

To preserve genome integrity, the S-phase checkpoint senses damaged DNA or nucleotide depletion and when necessary, arrests replication progression and delays cell division. Previous studies, based on two pol2 mutants have suggested the involvement of DNA polymerase epsilon (Pol ε) in sensing DNA replication accuracy in Saccharomyces cerevisiae. Here we have studied the involvement of Pol ε in sensing proper...

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PMID: 28107343
DOI: 10.1371/journal.pgen.1006572
PMCID: PMC5291541

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Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint.PMID 28107343Read ↗

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