Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toward optimization of AgoshRNA molecules that use a non-canonical RNAi pathway: variations in the top and bottom base pairs.

RNA biology - 1 Jan 2015

Herrera-Carrillo Elena, Harwig Alex, Berkhout Ben

Abstract excerpt

Short hairpin RNAs (shRNAs) are widely used for gene knockdown by inducing the RNA interference (RNAi) mechanism. The shRNA precursor is processed by Dicer into small interfering RNAs (siRNAs) and subsequently programs the RNAi-induced silencing complex (RISC) to find a complementary target mRNA (mRNA) for post-transcriptional gene silencing. Recent evidence indicates that shRNAs with a relatively short...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Argonaute Proteins
Share to Base Pairing
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Metabolic Networks and Pathways

Share to RNA Interference

Share to RNA, Messenger

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 25747107
DOI: 10.1080/15476286.2015.1022024
PMCID: PMC4615845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toward optimization of AgoshRNA molecules that use a non-canonical RNAi pathway: variations in the top and bottom base pairs.PMID 25747107Read ↗

Secondary structure RNA elements control the cleavage activity of DICER.Semantic proximity Read ↗

Use of steric blocking antisense oligonucleotides for the targeted inhibition of junction containing precursor microRNAsSemantic proximity Read ↗

Functional parameters of Dicer-independent microRNA biogenesis.Semantic proximity Read ↗

Improving the Precision of Base Editing by Bubble Hairpin Single Guide RNA.Semantic proximity Read ↗

RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression.Semantic proximity Read ↗

Development of a selection assay for small guide RNAs that drive efficient site-directed RNA editing.Semantic proximity Read ↗

A structure-activity relationship study of siRNAs with structural variations.Semantic proximity Read ↗

Human Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNASemantic proximity Read ↗

Progress toward the development of the small molecule equivalent of small interfering RNA.Semantic proximity Read ↗

RNA interference for the treatment of cancer.Semantic proximity Read ↗

A comprehensive analysis of precursor microRNA cleavage by human Dicer.Semantic proximity Read ↗

Biochemistry-informed design selects potent siRNAs against SARS-CoV-2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.