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Article

A structure-activity relationship study of siRNAs with structural variations.

Biochemical and biophysical research communications - 10 Aug 2007

Chang Chan Il, Hong Sun Woo, Kim Soyoun, Lee Dong-ki

Abstract excerpt

Specific knock-down of cellular gene expression using small interfering RNAs (siRNAs) is a powerful gene silencing technique in mammalian cells. Early siRNAs were double stranded, and 19-21bp in length, but several variations in siRNA structure have been introduced to achieve better silencing efficiency. In addition, siRNA modules have been incorporated into higher-order RNA structures to generate...

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PMID: 17577577
DOI: 10.1016/j.bbrc.2007.06.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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