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Article

RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression.

Nucleic acids research - 1 Oct 2013

Liu Jing, Pendergraff Hannah, Narayanannair K Jayaprakash, Lackey Jeremy G, Kuchimanchi Satya, Rajeev Kallanthottathil G, Manoharan Muthiah, Hu Jiaxin, Corey David R

Abstract excerpt

Abasic substitutions within DNA or RNA are tools for evaluating the impact of absent nucleobases. Because of the importance of abasic sites in genetic damage, most research has involved DNA. Little information is available on the impact of abasic substitutions within RNA or on RNA interference (RNAi). Here, we examine the effect of abasic substitutions on RNAi and allele-selective gene silencing. Huntington's...

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Identifiers

PMID: 23887934
DOI: 10.1093/nar/gkt594
PMCID: PMC3794577

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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