Article

Use of steric blocking antisense oligonucleotides for the targeted inhibition of junction containing precursor microRNAs

2024-04-08

Abstract excerpt

<h4>ABSTRACT</h4> Antisense oligonucleotides (ASOs) are widely used as therapeutics for neurodegenerative diseases, cancers, and virus infections. One class of ASOs functions to enhance protein expression by sequestering the mature microRNA (miRNA) in a double-stranded structure within the RNA-induced silencing complex (RISC). An alternative approach for the targeted control of gene expression is to use ASOs that...

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Literature Corpus work: 6ebf1a6b-5736-5237-a313-a024a943bb3e
DOI: 10.1101/2024.04.08.588531

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