Article
A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder.
Scientific reports - 6 Mar 2015
Wang Liang-Jen, Lee Sheng-Yu, Chen Shiou-Lan, Chang Yun-Hsuan, Chen Po See, Huang San-Yuan, Tzeng Nian-Sheng, Chen Kao Chin, Lee I Hui, Wang Tzu-Yun, Yang Yen Kuang, Lu Ru-Band
Abstract excerpt
Bipolar II disorder (BP-II), characterized by recurrent dysregulation of mood, is a serious and chronic psychiatric illness. However, BP-II is commonly under-recognized, even in psychiatric settings. Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (BPD), it seems essential to investigate dopamine-related genes like the catechol-O-methyltransferase (COMT) gene,...
Topics
- Adult
- Alleles
- Asian People
- Bipolar Disorder
- Case-Control Studies
- Catechol O-Methyltransferase
- China
- Epistasis, Genetic
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genetic Variation