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Article

A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder.

Scientific reports - 6 Mar 2015

Wang Liang-Jen, Lee Sheng-Yu, Chen Shiou-Lan, Chang Yun-Hsuan, Chen Po See, Huang San-Yuan, Tzeng Nian-Sheng, Chen Kao Chin, Lee I Hui, Wang Tzu-Yun, Yang Yen Kuang, Lu Ru-Band

Abstract excerpt

Bipolar II disorder (BP-II), characterized by recurrent dysregulation of mood, is a serious and chronic psychiatric illness. However, BP-II is commonly under-recognized, even in psychiatric settings. Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (BPD), it seems essential to investigate dopamine-related genes like the catechol-O-methyltransferase (COMT) gene,...

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Source

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Identifiers

PMID: 25744938
DOI: 10.1038/srep08813
PMCID: PMC4351536

Genes

COMT
MTHFR

Variants

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder.PMID 25744938Read ↗

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The T Allele of MTHFR c.C677T and Its Synergism with G (Val 158) Allele of COMT c.G472A Polymorphism Are Associated with the Risk of Bipolar I Disorder.Semantic proximity Read ↗

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