Article
Association between a COMT polymorphism and clinical response to risperidone treatment: a pharmacogenetic study.
Psychiatric genetics - 1 Dec 2012
Zhao Qing-Zhu, Liu Bao-Cheng, Zhang Jing, Wang Lei, Li Xing-Wang, Wang Yang, Ji Jue, Yang Feng-Ping, Wan Chun-Ling, Xu Yi-Feng, Feng Guo-Yin, He Lin, He Guang
Abstract excerpt
A total of 130 Chinese schizophrenic patients (45 male, 85 female) were enrolled in the study. Clinical efficacy was determined using Brief Psychiatric Rating Scale (BPRS) scores. We genotyped 10 single-nucleotide polymorphisms (SNPs) of the catechol-O-methyl transferase gene (COMT) in our patients and re-examined them for association with changes in BPRS scores after 8 weeks of risperidone monotherapy. COMT is...
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