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Article

No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. Biomed European Bipolar Collaborative Group.

The British journal of psychiatry : the journal of mental science - 1 Jun 1997

Abstract excerpt

BACKGROUND: There is compelling evidence for the existence of susceptibility genes for bipolar disorder. Association studies using functional DNA variations are an important approach for identifying these genes. The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamine neurotransmitters and is a candidate for involvement in bipolar disorder. Recently a common functional...

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Source

Identifiers

PMID: 9330018
DOI: 10.1192/bjp.170.6.526

Genes

COMT

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. Biomed European Bipolar Collaborative Group.PMID 9330018Read ↗

Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder.Semantic proximity Read ↗

Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene.Semantic proximity Read ↗

Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder.Semantic proximity Read ↗

The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis.Semantic proximity Read ↗

The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons.Semantic proximity Read ↗

Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.Semantic proximity Read ↗

Association study of candidate variants of COMT with neuroticism, anxiety and depression.Semantic proximity Read ↗

Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder.Semantic proximity Read ↗

No evidence for an association of affective disorders with high- or low-activity allele of catechol-o-methyltransferase gene.Semantic proximity Read ↗

A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder.Semantic proximity Read ↗

COMT: a common susceptibility gene in bipolar disorder and schizophrenia.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder.Semantic proximity Read ↗

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