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Article

Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population.

Journal of affective disorders - 1 Jun 2014

Shen Xinhua, Wu Yanfeng, Guan Tiefeng, Wang Xiaoquan, Qian Mincai, Lin Min, Shen Zhongxia, Sun Jushui, Zhong Hua, Yang Jianhong, Li Liang, Yuan Yonggui

Abstract excerpt

BACKGROUND: In several previous biochemical and genetic studies, the Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) and the C677T polymorphism of Methylenetetrahydrofolate reductase (MTHFR) have been suggested to be involved in the pathogenesis as well as the treatment response of major depressive disorder (MDD), but the results have been inconsistent. In this study, we...

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Source

Identifiers

PMID: 24751310
DOI: 10.1016/j.jad.2014.03.008

Genes

COMT
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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