The COMT and DRD3 genes interacted in bipolar I but not bipolar II disorder.

doi:10.3109/15622975.2010.505298

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Article

The COMT and DRD3 genes interacted in bipolar I but not bipolar II disorder.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Aug 2011

Lee Sheng-Yu, Chen Shiou-Lan, Chen Shih-Heng, Huang San-Yuan, Tzeng Nian-Sheng, Chang Yun-Hsuan, Wang Chen-Lin, Lee I Hui, Yeh Tzung Lieh, Yang Yen Kuang, Lu Ru-Band

Abstract excerpt

OBJECTIVES. Clarifying the association between bipolar I and bipolar II disorders at the genetic level is essential for improving our understanding of them. In this study, we evaluated the hypothesis that the dopaminergic polymorphisms are risk factors for bipolar disorders. We examined the association between the catechol-O-methyltransferase (COMT) Val158Met and dopamine D3 receptor (DRD3) Ser9Gly polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20698735
DOI: 10.3109/15622975.2010.505298

Genes

COMT
DRD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.