Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The T Allele of MTHFR c.C677T and Its Synergism with G (Val 158) Allele of COMT c.G472A Polymorphism Are Associated with the Risk of Bipolar I Disorder.

Genetic testing and molecular biomarkers - 1 Sept 2016

Rahimi Ziba, Kakabaraee Keivan, Garavand Amin, Rahimi Zohreh

Abstract excerpt

AIMS: The aims of the present study were to investigate the association between methylenetetrahydrofolate reductase (MTHFR) c.C677T (p.A222V) and catechol-O-methyltransferase (COMT) c.G472A (p.V158M) polymorphisms and their synergism with respect to bipolar I disorder (BID). METHODS: Within an ethnic Kurdish population from Western Iran the MTHFR c.C677T and COMT c.G472A polymorphisms were studied in 150 patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Gene Frequency

Share to Genetic Association Studies

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Risk Factors

Source

Identifiers

PMID: 27447284
DOI: 10.1089/gtmb.2016.0061

Genes

MTHFR
BID
COMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The T Allele of MTHFR c.C677T and Its Synergism with G (Val 158) Allele of COMT c.G472A Polymorphism Are Associated with the Risk of Bipolar I Disorder.PMID 27447284Read ↗

A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder.Semantic proximity Read ↗

Association of 677C>T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene with bipolar disorder and schizophrenia.Semantic proximity Read ↗

The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis.Semantic proximity Read ↗

Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood disorders.Semantic proximity Read ↗

The COMT and DRD3 genes interacted in bipolar I but not bipolar II disorder.Semantic proximity Read ↗

Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis.Semantic proximity Read ↗

C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies.Semantic proximity Read ↗

Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene.Semantic proximity Read ↗

C677T methylenetetrahydrofolate reductase gene polymorphisms in bipolar disorder: an association study in the Chinese population and a meta-analysis of genetic association studies.Semantic proximity Read ↗

MTHFD 1958G>A and MTR 2756A>G polymorphisms are associated with bipolar disorder and schizophrenia.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) polymorphism susceptibility to schizophrenia and bipolar disorder: an updated meta-analysis.Semantic proximity Read ↗

Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.