Article
Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes.
Circulation. Genomic and precision medicine - 1 Aug 2021
Lu Yingchang, Dimitrov Latchezar, Chen Shyh-Huei, Bielak Lawrence F, Bis Joshua C, Feitosa Mary F, Lu Lingyi, Kavousi Maryam, Raffield Laura M, Smith Albert V, Wang Lihua, Weiss Stefan, Yao Jie, Zhu Jiaxi, Gudmundsson Elias F, Gudmundsdottir Valborg, Bos Daniel, Ghanbari Mohsen, Ikram M Arfan, Hwang Shih-Jen, Taylor Kent D, Budoff Matthew J, Gíslason Gauti K, O'Donnell Christopher J, An Ping, Franceschini Nora, Freedman Barry I, Fu Yi-Ping, Guo Xiuqing, Heiss Gerardo, Kardia Sharon L R, Wilson James G, Langefeld Carl D, Schminke Ulf, Uitterlinden André G, Lange Leslie A, Peyser Patricia A, Gudnason Vilmundur G, Psaty Bruce M, Rotter Jerome I, Bowden Donald W, Ng Maggie C Y
Abstract excerpt
BACKGROUND: Coronary artery calcification (CAC) and carotid artery intima-media thickness (cIMT) are measures of subclinical atherosclerosis in asymptomatic individuals and strong risk factors for cardiovascular disease. Type 2 diabetes (T2D) is an independent cardiovascular disease risk factor that accelerates atherosclerosis. METHODS: We performed meta-analyses of genome-wide association studies in up to 2500...
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