A Specific IL6 Polymorphic Genotype Modulates the Risk of Trypanosoma cruzi Parasitemia While IL18, IL17A, and IL1B Variant Profiles and HIV Infection Protect Against Cardiomyopathy in Chagas Disease.

doi:10.3389/fimmu.2020.521409

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A Specific IL6 Polymorphic Genotype Modulates the Risk of Trypanosoma cruzi Parasitemia While IL18, IL17A, and IL1B Variant Profiles and HIV Infection Protect Against Cardiomyopathy in Chagas Disease.

Frontiers in immunology - 1 Jan 2020

Gomes Dos Santos Alexandra, Watanabe Elieser Hitoshi, Ferreira Daiane Tomomi, Oliveira Jamille, Nakanishi Érika Shimoda, Oliveira Claudia Silva, Bocchi Edimar, Novaes Cristina Terra Gallafrio, Cruz Fatima, Carvalho Noemia Barbosa, Sato Paula Keiko, Yamashiro-Kanashiro Edite Hatsumi, Pontillo Alessandra, de Freitas Vera Lucia Teixeira, Onuchic Luiz Fernando, Shikanai-Yasuda Maria Aparecida

Abstract excerpt

Background: Chagas disease caused by Trypanosoma cruzi (T. cruzi) affects approximately six million individuals worldwide. Clinical manifestations are expected to occur due to the parasite persistence and host immune response. Herein we investigated potential associations between IL1B, IL6, IL17A, or IL18 polymorphism profiles and cardiomyopathy or T. cruzi parasitemia, as well as the impact of HIV infection on...

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PMID: 33193300
DOI: 10.3389/fimmu.2020.521409
PMCID: PMC7642879

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