Article
The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression.
Pharmacogenetics and genomics - 1 May 2015
Langaee Taimour Y, Zhong Guo, Li Wenjun, Hamadeh Issam, Solayman Mohamed Hassan M, McDonough Caitrin W, Stacpoole Peter W, James Margaret O
Abstract excerpt
BACKGROUND/OBJECTIVES: The zeta-1 family isoform of GST biotransforms the investigational drug dichloroacetate (DCA) and certain other halogenated carboxylic acids. Haplotype variability in GSTZ1 influences the kinetics and, possibly, the toxicity of DCA. DCA metabolism correlates with expression of the GSTZ1 protein, so it is important to document variables that affect expression. Following up on a limited...
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