Article
Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
Drug metabolism and disposition: the biological fate of chemicals - 1 Feb 2012
Li Wenjun, Gu Yuan, James Margaret O, Hines Ronald N, Simpson Pippa, Langaee Taimour, Stacpoole Peter W
Abstract excerpt
Glutathione transferase ζ 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several α-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors. Age-related differences have been suggested in DCA pharmacotoxicology, but no information is available on GSTZ1...
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