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Article

Glutathione S-transferase T1 and M1: gene sequence variation and functional genomics.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2007

Moyer Ann M, Salavaggione Oreste E, Hebbring Scott J, Moon Irene, Hildebrandt Michelle A T, Eckloff Bruce W, Schaid Daniel J, Wieben Eric D, Weinshilboum Richard M

Abstract excerpt

PURPOSE: The glutathione S-transferases (GSTs) catalyze the glutathione conjugation of reactive electrophiles, including carcinogens and many antineoplastic drugs. GSTT1 and GSTM1 are polymorphically deleted, but the full range of genetic variation in these two genes has not yet been explored. We set out to systematically identify common polymorphisms in GSTT1 and GSTM1, followed by functional genomic studies....

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Source

Identifiers

PMID: 18056202
DOI: 10.1158/1078-0432.CCR-07-0635

Genes

GSTT1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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