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Genetic Polymorphism in Glutathione Transferases (GST): Population distribution of GSTM1, T1, and P1 conjugating activity.

Journal of toxicology and environmental health. Part B, Critical reviews - 1 Jan 2009

Ginsberg Gary, Smolenski Susan, Hattis Dale, Guyton Kathryn Z, Johns Douglas O, Sonawane Babasaheb

Abstract excerpt

Glutathione transferases (GST) catalyze the conjugation of glutathione (GSH) with electrophiles, many of which may otherwise interact with protein or DNA. In select cases such as halogenated solvents, GST-mediated conjugation may lead to a more toxic or mutagenic metabolite. Polymorphisms that exert substantial effects on GST function were noted in human populations for several isozymes. This analysis focuses on...

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Genetics, Population
Genotype
Glutathione S-Transferase pi
Glutathione Transferase
Monte Carlo Method

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

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Identifiers

PMID: 20183528
DOI: 10.1080/10937400903158375

Genes

GSTM1
GSTP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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