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Article

Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay.

Genetic testing and molecular biomarkers - 1 Apr 2018

Langaee Taimour, Wagner Richard, Horne Lloyd P, Lawson Lee Ann, Becker Cecilia, Shahin Mohamed, Starostik Petr, Stacpoole Peter W

Abstract excerpt

AIMS: Dichloroacetate (DCA) represents the first targeted therapy for pyruvate dehydrogenase complex deficiency; it is metabolized by glutathione transferase zeta1 (GSTZ1). Variation in the GSTZ1 haplotype is the principal variable influencing DCA kinetics and dynamics in humans. We aimed to develop a sensitive and rapid clinical genetic screening test for determining GSTZ1 haplotype status in individuals who...

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Identifiers

PMID: 29641284
DOI: 10.1089/gtmb.2017.0261

Genes

GSTZ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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