Glutathione S-transferase polymorphisms: cancer incidence and therapy.

doi:10.1038/sj.onc.1209373

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Article

Glutathione S-transferase polymorphisms: cancer incidence and therapy.

Oncogene - 13 Mar 2006

McIlwain C C, Townsend D M, Tew K D

Abstract excerpt

The super family of glutathione S-transferases (GSTs) is composed of multiple isozymes with significant evidence of functional polymorphic variation. Over the last three decades, data from cancer studies have linked aberrant expression of GST isozymes with the development and expression of resistance to a variety of chemicals, including cancer drugs. This review addresses how differences in the human GST isozyme...

Topics

Drug Resistance, Neoplasm
Epidemiologic Studies
Genetic Predisposition to Disease
Glutathione Transferase
Humans
Isoenzymes
Neoplasms
Polymorphism, Genetic
Prognosis
Treatment Outcome

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Identifiers

PMID: 16550164
DOI: 10.1038/sj.onc.1209373
PMCID: PMC6361140

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