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Article

Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.

Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2018

Zhong Guo, James Margaret O, Smeltz Marci G, Jahn Stephan C, Langaee Taimour, Simpson Pippa, Stacpoole Peter W

Abstract excerpt

Glutathione transferase zeta1 (GSTZ1) catalyzes glutathione (GSH)-dependent dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in metabolic disorders and cancer. GSTZ1 is expressed in both hepatic cytosol and mitochondria. Here, we examined the ontogeny and characterized the properties of human mitochondrial GSTZ1. GSTZ1 expression and activity with DCA were determined in...

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Source

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Identifiers

PMID: 29853471
DOI: 10.1124/dmd.118.081810
PMCID: PMC6038028

Genes

GSTZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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