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Article

Pharmacogenetic considerations with dichloroacetate dosing.

Pharmacogenomics - 1 May 2016

James Margaret O, Stacpoole Peter W

Abstract excerpt

The investigational drug dichloroacetate (DCA) is a metabolic regulator that has been successfully used to treat acquired and congenital metabolic diseases and, recently, solid tumors. Its clinical use has revealed challenges in selecting appropriate doses. Chronic administration of DCA leads to inhibition of DCA metabolism and potential accumulation to levels that result in side effects. This is because...

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Identifiers

PMID: 27143230
DOI: 10.2217/pgs-2015-0012
PMCID: PMC5558523

Genes

GSTZ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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