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Article

The analysis of GSTA1 promoter genetic and functional diversity of human populations.

Scientific reports - 3 Mar 2021

Mlakar Vid, Curtis Patricia Huezo-Diaz, Armengol Marc, Ythier Victor, Dupanloup Isabelle, Hassine Khalil Ben, Lesne Laurence, Murr Rabih, Mlakar Simona Jurkovic, Nava Tiago, Ansari Marc

Abstract excerpt

GSTA1 encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. GSTA1 has several functional SNPs within its promoter region that are responsible for a change in its expression by altering promoter function. This study aims to investigate distributions of GSTA1...

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Identifiers

PMID: 33658540
DOI: 10.1038/s41598-021-83996-2
PMCID: PMC7930039

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