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Article

Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.

Journal of clinical pharmacology - 1 Jun 2012

Shroads Albert L, Langaee Taimour, Coats Bonnie S, Kurtz Tracie L, Bullock John R, Weithorn David, Gong Yan, Wagner David A, Ostrov David A, Johnson Julie A, Stacpoole Peter W

Abstract excerpt

Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway. The authors postulated that polymorphisms in GSTz1/MAAI modify the toxicokinetics of DCA. GSTz1/MAAI haplotype significantly affected...

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Identifiers

PMID: 21642471
DOI: 10.1177/0091270011405664
PMCID: PMC3786668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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