Article

Adverse Effects of Culture Media on Human Pluripotent Stem Cells

2016-08-04

Abstract excerpt

<h4>Summary</h4> Culture conditions play an important role in regulating the genomic integrity of HPSCs. We report that HPSCs cultured in Essential 8 (E8) and mTeSR, two widely used media for off-feeder culturing of HPSCs, had many fold higher levels of ROS and higher mitochondrial potential than cells cultured in KSR containing media. HPSCs also exhibited increased levels of 8-hydroxyguanosine, phospho-histone-H...

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Literature Corpus work: c26aca72-94df-5986-8a2f-95c29a5e09c2
DOI: 10.1101/067868

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