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Article

IL-4-secreting secondary T follicular helper (Tfh) cells arise from memory T cells, not persisting Tfh cells, through a B cell-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2015

Fairfax Keke C, Everts Bart, Amiel Eyal, Smith Amber M, Schramm Gabriele, Haas Helmut, Randolph Gwendalyn J, Taylor Justin J, Pearce Edward J

Abstract excerpt

Humoral immunity requires cross-talk between T follicular helper (Tfh) cells and B cells. Nevertheless, a detailed understanding of this intercellular interaction during secondary immune responses is lacking. We examined this by focusing on the response to a soluble, unadjuvanted, pathogen-derived Ag (soluble extract of Schistosoma mansoni egg [SEA]) that induces type 2 immunity. We found that activated Tfh cells...

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Identifiers

PMID: 25712216
DOI: 10.4049/jimmunol.1401225
PMCID: PMC4495582

Genes

SEA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IL-4-secreting secondary T follicular helper (Tfh) cells arise from memory T cells, not persisting Tfh cells, through a B cell-dependent mechanism.PMID 25712216Read ↗

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