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Article

B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.

The Journal of experimental medicine - 3 Feb 2020

Arroyo E Nicole, Pepper Marion

Abstract excerpt

CD4+ T follicular helper (Tfh) cells dominate the acute response to a blood-stage Plasmodium infection and provide signals to direct B cell differentiation and protective antibody expression. We studied antigen-specific CD4+ Tfh cells responding to Plasmodium infection in order to understand the generation and maintenance of the Tfh response. We discovered that a dominant, phenotypically stable, CXCR5+ Tfh...

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Share to Antibodies, Protozoan
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Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Organisms, Genetically Modified

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Share to T-Lymphocytes, Helper-Inducer

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Identifiers

PMID: 31748243
DOI: 10.1084/jem.20190849
PMCID: PMC7041722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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