Article
B cells induced by Schistosoma japonicum infection display diverse regulatory phenotypes and modulate CD4+ T cell response.
Parasites & vectors - 20 Mar 2020
Xiao Junli, Guan Fei, Sun Li, Zhang Yijie, Zhang Xiaoyan, Lu Shengjun, Liu Wenqi
Abstract excerpt
BACKGROUND: The increased activity of regulatory B cells (Breg) is known to be involved in immunosuppression during helminth infection, which is characterized by inducing IL-10-producing Breg cells. However, the current knowledge of B cell subsets differentiation and IL-10-independent immunoregulatory mechanisms of B cells in schistosomiasis is insufficient. METHODS: BALB/c mice were percutaneously infected with...
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