Article
B cells induced by Schistosoma japonicum infection display diverse regulatory phenotypes and modulate CD4+ T cell response.
Parasites & vectors - 20 Mar 2020
Xiao Junli, Guan Fei, Sun Li, Zhang Yijie, Zhang Xiaoyan, Lu Shengjun, Liu Wenqi
Abstract excerpt
BACKGROUND: The increased activity of regulatory B cells (Breg) is known to be involved in immunosuppression during helminth infection, which is characterized by inducing IL-10-producing Breg cells. However, the current knowledge of B cell subsets differentiation and IL-10-independent immunoregulatory mechanisms of B cells in schistosomiasis is insufficient. METHODS: BALB/c mice were percutaneously infected with...
Topics
- Animals
- B-Lymphocyte Subsets
- B-Lymphocytes
- B7-H1 Antigen
- CD4-Positive T-Lymphocytes
- Cell Differentiation
- Disease Models, Animal
- Female
- Interleukin-10
- Liver
- Mice