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Article

CD4+ Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1992

Vella A T, Pearce E J

Abstract excerpt

Data from recent studies of murine schistosomiasis mansoni have indicated that certain characteristics of this infection, such as eosinophilia and elevated IgE, are due largely to the induction of Th2-like immune responses by parasite ova. The present study was designed to examine more closely the genesis and development of these skewed Th responses to schistosome eggs. Accordingly, eggs isolated from infected...

Topics

Animals
CD4-Positive T-Lymphocytes
Down-Regulation
Female
Interferon-gamma
Interleukin-10
Interleukin-2
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Ovum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Lymphocyte Homing

Schistosomiasis mansoni

T-Lymphocytes, Helper-Inducer

Source

Identifiers

PMID: 1347553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1347553-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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