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Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection

1 Dec 2020

Abstract excerpt

CD4 + T follicular helper cells (Tfh) are key drivers of antibody development. During Plasmodium falciparum malaria in children, the activation of Tfh is restricted to the Th1 subset and not associated with antibody levels. To identify Tfh subsets that are associated with antibody development in malaria, we assess Tfh and antibodies longitudinally in human volunteers with experimental P. falciparum infection. Tfh...

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PMID: 33377128
DOI: 10.1016/j.xcrm.2020.100157

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