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Article

Regulation of granulomatous inflammation in murine schistosomiasis. IV. Antigen-induced suppressor T cells down-regulate proliferation and IL-2 production.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1990

Fidel P L, Boros D L

Abstract excerpt

In murine schistosomiasis mansoni the cell-mediated immune response to the deposited eggs is mediated by CD4+ delayed-type hypersensitivity effector T (TDH) cells that produce vigorous granulomatous responses in the liver and intestines of acutely infected animals. The response is significantly down-modulated in chronically infected mice by Ag-specific Ts cells. The present study was undertaken to establish an in...

Topics

Animals
Antigens, Differentiation, T-Lymphocyte
Antigens, Helminth
CD8 Antigens
Down-Regulation
Female
Granuloma
Interleukin-2
Lymphocyte Activation
Mice
Mice, Inbred CBA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Schistosomiasis

Spleen

T-Lymphocytes, Regulatory

Source

Identifiers

PMID: 2143210

Genes

SEA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2143210-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Regulation of granulomatous inflammation in murine schistosomiasis. IV. Antigen-induced suppressor T cells down-regulate proliferation and IL-2 production.PMID 2143210Read ↗

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