Article
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.
Lancet (London, England) - 29 Jan 2011
Reilly Muredach P, Li Mingyao, He Jing, Ferguson Jane F, Stylianou Ioannis M, Mehta Nehal N, Burnett Mary Susan, Devaney Joseph M, Knouff Christopher W, Thompson John R, Horne Benjamin D, Stewart Alexandre F R, Assimes Themistocles L, Wild Philipp S, Allayee Hooman, Nitschke Patrick Linsel, Patel Riyaz S, Martinelli Nicola, Girelli Domenico, Quyyumi Arshed A, Anderson Jeffrey L, Erdmann Jeanette, Hall Alistair S, Schunkert Heribert, Quertermous Thomas, Blankenberg Stefan, Hazen Stanley L, Roberts Robert, Kathiresan Sekar, Samani Nilesh J, Epstein Stephen E, Rader Daniel J
Abstract excerpt
BACKGROUND: We tested whether genetic factors distinctly contribute to either development of coronary atherosclerosis or, specifically, to myocardial infarction in existing coronary atherosclerosis. METHODS: We did two genome-wide association studies (GWAS) with coronary angiographic phenotyping in participants of European ancestry. To identify loci that predispose to angiographic coronary artery disease (CAD),...
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