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Article

Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis.

Atherosclerosis - 1 Mar 2020

Pu Xiangyuan, Chan Kenneth, Yang Wei, Xiao Qingzhong, Zhang Li, Moore Andrew D, Liu Chuanju, Webb Tom R, Caulfield Mark J, Samani Nilesh J, Zhu Jianhua, Ye Shu

Abstract excerpt

BACKGROUND AND AIMS: Recent studies have unveiled an association between ADAMTS7 gene variation and coronary artery disease (CAD) caused by atherosclerosis. We investigated if the ADAMTS7 Serine214-to-Proline substitution arising from a CAD-associated variant affected angiogenesis, since neovascularization plays an important role in atherosclerosis. METHODS AND RESULTS: ADAMTS7 knockdown in vascular endothelial...

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PMID: 32005000
DOI: 10.1016/j.atherosclerosis.2020.01.015

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