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Article

Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2017

Nicolaou Alexandros, Zhao Zhen, Northoff Bernd H, Sass Kristina, Herbst Andreas, Kohlmaier Alexander, Chalaris Athena, Wolfrum Christian, Weber Christian, Steffens Sabine, Rose-John Stefan, Teupser Daniel, Holdt Lesca M

Abstract excerpt

OBJECTIVE: ADAM17 (a disintegrin and metalloproteinase 17) is a sheddase releasing different types of membrane-bound proteins, including adhesion molecules, cytokines, and their receptors as well as inflammatory mediators. Because these substrates modulate important mechanisms of atherosclerosis, we hypothesized that ADAM17 might be involved in the pathogenesis of this frequent disease. APPROACH AND RESULTS:...

Read the complete abstract on PubMed

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Share to ADAM17 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Diseases

Share to Atherosclerosis

Share to Muscle, Smooth, Vascular

Share to Plaque, Atherosclerotic

Share to Receptors, LDL

Share to Receptors, Tumor Necrosis Factor, Type II

Source

Identifiers

PMID: 28062509
DOI: 10.1161/ATVBAHA.116.308682

Genes

ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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