ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant.

doi:10.1016/j.ajhg.2013.01.012

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Article

ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant.

American journal of human genetics - 7 Mar 2013

Pu Xiangyuan, Xiao Qingzhong, Kiechl Stefan, Chan Kenneth, Ng Fu Liang, Gor Shivani, Poston Robin N, Fang Changcun, Patel Ashish, Senver Ece C, Shaw-Hawkins Sue, Willeit Johann, Liu Chuanju, Zhu Jianhua, Tucker Arthur T, Xu Qingbo, Caulfield Mark J, Ye Shu

Abstract excerpt

Recent genome-wide association studies have revealed an association between variation at the ADAMTS7 locus and susceptibility to coronary artery disease (CAD). Furthermore, in a population-based study cohort, we observed an inverse association between atherosclerosis prevalence and rs3825807, a nonsynonymous SNP (A to G) leading to a Ser-to-Pro substitution in the prodomain of the protease ADAMTS7. In light of...

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Identifiers

PMID: 23415669
DOI: 10.1016/j.ajhg.2013.01.012
PMCID: PMC3591856

Genes

ADAMTS7
CAD

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