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Article

Genetic Ablation of <i>Adamts13</i> Gene Dramatically Accelerates the Formation of Early Atherosclerosis in a Murine Model

1 Jun 2012

Abstract excerpt

OBJECTIVE: ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats-13) cleaves von Willebrand factor, thereby modulating thrombosis and inflammation. Low plasma ADAMTS13 activity is associated with cardiovascular events, including myocardial and cerebral infarction. Here, we investigated the role of ADAMTS13 in the development of early atherosclerosis in a murine model. METHODS AND RESULTS:...

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PMID: 22652598
DOI: 10.1161/atvbaha.112.247262

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