Article
p27(kip1) Knockout enhances collateralization in response to hindlimb ischemia.
Journal of vascular surgery - 1 May 2016
Ankri-Eliahoo Galit, Weitz Kevin, Cox Timothy C, Tang Gale L
Abstract excerpt
OBJECTIVE: The natural response to arterial occlusive disease is enlargement of collaterals; however, the molecular factors that control collateralization are not well understood. The gene p27(Kip1) (p27) affects human response to arterial injury. Previous studies have shown that overexpression of p27 inhibits vascular endothelial and vascular smooth muscle cell (VSMC) proliferation and angiogenesis. To test the...
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