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Article

The onset of PI3K-related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib.

EMBO molecular medicine - 7 Jul 2022

Kobialka Piotr, Sabata Helena, Vilalta Odena, Gouveia Leonor, Angulo-Urarte Ana, Muixí Laia, Zanoncello Jasmina, Muñoz-Aznar Oscar, Olaciregui Nagore G, Fanlo Lucia, Esteve-Codina Anna, Lavarino Cinzia, Javierre Biola M, Celis Veronica, Rovira Carlota, López-Fernández Susana, Baselga Eulàlia, Mora Jaume, Castillo Sandra D, Graupera Mariona

Abstract excerpt

Low-flow vascular malformations are congenital overgrowths composed of abnormal blood vessels potentially causing pain, bleeding and obstruction of different organs. These diseases are caused by oncogenic mutations in the endothelium, which result in overactivation of the PI3K/AKT pathway. Lack of robust in vivo preclinical data has prevented the development and translation into clinical trials of specific...

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Identifiers

PMID: 35695059
DOI: 10.15252/emmm.202115619
PMCID: PMC9260211

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