Article

Dickkopf-1 accentuates neuronal damage upon multifocal cerebral microinfarctions by impairing vascular and immune responses

2025-10-29

Abstract excerpt

<title>Abstract</title> <p>Cerebral small vessel disease (cSVD) associated with the occlusion of small penetrating arterioles leading to multifocal microinfarcts, constitutes common microangiopathies affecting brain functions. Dickkopf-1 (DKK1) is a potent inhibitor of the canonical Wnt pathway, which plays key roles in regulating neurovascular and immune functions. DKK1 levels are reported to be increased in cer...

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Literature Corpus work: fc4c512a-5319-53ad-969b-4fea5fa3a90d
DOI: 10.21203/rs.3.rs-7622603/v1

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