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Article

CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels.

Circulation research - 22 Jan 2016

Nanda Vivek, Downing Kelly P, Ye Jianqin, Xiao Sophia, Kojima Yoko, Spin Joshua M, DiRenzo Daniel, Nead Kevin T, Connolly Andrew J, Dandona Sonny, Perisic Ljubica, Hedin Ulf, Maegdefessel Lars, Dalman Jessie, Guo Liang, Zhao XiaoQing, Kolodgie Frank D, Virmani Renu, Davis Harry R, Leeper Nicholas J

Abstract excerpt

RATIONALE: Genetic variation at the chromosome 9p21 cardiovascular risk locus has been associated with peripheral artery disease, but its mechanism remains unknown. OBJECTIVE: To determine whether this association is secondary to an increase in atherosclerosis, or it is the result of a separate angiogenesis-related mechanism. METHODS AND RESULTS: Quantitative evaluation of human vascular samples revealed that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26596284
DOI: 10.1161/CIRCRESAHA.115.307906
PMCID: PMC4740238

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