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Article

Leptin Induces Sca-1+ Progenitor Cell Migration Enhancing Neointimal Lesions in Vessel-Injury Mouse Models.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2017

Xie Yao, Potter Claire M F, Le Bras Alexandra, Nowak Witold N, Gu Wenduo, Bhaloo Shirin Issa, Zhang Zhongyi, Hu Yanhua, Zhang Li, Xu Qingbo

Abstract excerpt

OBJECTIVE: Leptin is an adipokine initially thought to be a metabolic factor. Recent publications have shown its roles in inflammation and vascular disease, to which Sca-1+ vascular progenitor cells within the vessel wall may contribute. We sought to elucidate the effects of leptin on Sca-1+ progenitor cells migration and neointimal formation and to understand the underlying mechanisms. APPROACH AND RESULTS:...

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Identifiers

PMID: 28935755
DOI: 10.1161/ATVBAHA.117.309852
PMCID: PMC5671780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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