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Article

Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway.

International journal of cardiology - 1 Feb 2017

Xiao Jiajun, Jin Kaiyue, Wang Jiping, Ma Jing, Zhang Jin, Jiang Nan, Wang Huijun, Luo Xinping, Fei Jian, Wang Zhugang, Yang Xiao, Ma Duan

Abstract excerpt

BACKGROUND: Tissue factor pathway inhibitor-1 (TFPI-1) has multiple functions and its precise role and molecular mechanism during the development of atherosclerosis are not clear. OBJECTIVES: To determine the effect and molecular mechanism of TFPI-1 deficiency in vascular smooth muscle cells (VSMCs) in atherosclerosis in the apolipoprotein E knockout (ApoE-/-) mouse. METHODS AND RESULTS: A mouse model with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27875740
DOI: 10.1016/j.ijcard.2016.11.195

Genes

TFPI
AMOT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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